Sodium administration, and the maintenance of high-normal sodium levels, may also reduce the severity of lithium toxicity by removing the dangerous intracellular fraction of lithium from inside excitable cells. Hemodialysis, and, to a lesser extent, peritoneal dialysis, will both rapidly eliminate lithium from the body. A meta-analysis by Geddes et al. Oral Solution: 5 mL (8 mEq lithium) three times daily Each 5 mL of Lithium Oral Solution contains 8 mEq of lithium ion (Li +) which is equivalent to the amount of lithium in 300 mg of lithium carbonate. there is no antidote for lithium toxicity. Lithium has compelling evidence in the treatment of mania, acute bipolar depression and prophylaxis in bipolar disorder. Initial general anti-poisoning measures, such as gastric lavage, may be helpful, but the ultimate success of treatment depends upon the elimination of lithium from the body. In some cases you can use low dose dopamine to increase lithium excretion, but the use of forced diuresis is. Moderate and severe toxicity both require more aggressive approaches. Lithium can be eliminated via haemodialysis, it is reserved for patients with established renal impairment or those with clinical features of neurotoxicity. Mild toxicity can often be managed successfully with minimal intervention often only cessation or reduction of lithium doses is sufficient. In rare cases, lithium may lead to a reversible condition known as diabetes insipidus. What are possible side effects of lithium Sedation, nausea, loss of appetite, mild diarrhea, dizziness, fine hand tremors, increased production of urine and excessive thirst are common side effects. Acute lithium toxicity is generally subdivided into three grades: mild, moderate, and severe. A specific antidote for lithium does not exist. Consequently recognition and treatment of lithium toxicity has also become more important. Although accurate epidemiological data is not available, it is generally agreed that acute lithium toxicity is becoming a more frequent problem.
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